After Dark: Manganese


After Dark: Manganese
Thursday, December 21, 2017 • 6:00–10:00 p.m.

Everything Matters: Manganese
8:00 p.m.
Phyllis C. Wattis Webcast Studio

Come be in your elements with Exploratorium host and scientific raconteur Ron Hipschman. Follow tales of intrigue and invention, join in dynamic demonstrations, and uncover fascinating connections between individual elements and our collective human experience.

Learn more about the series, Everything Matters: Tales from the Periodic Table.

Brittle, gray manganese is a transition metal that lends its strength to steel and other alloys, and shows its colors in a variety of oxidation states. An essential element for life, manganese plays a key role in producing oxygen during photosynthesis, and helps our cells metabolize proteins, fats, and carbohydrates. While we maintain a balance of around twelve milligrams of manganese in our bodies, absorbing too much of the metal proves toxic.

Join Suzanne Angeli of the Buck Institute on Aging to learn how environmental exposure to manganese increases one’s risk of developing Parkinson’s Disease. Occupational exposure to high levels of the element can also cause a syndrome known as manganism, which has symptoms very similar to PD. By modeling manganism in a microscopic worm known as C. elegans, Angeli aims to identify new therapeutic interventions to ameliorate the symptoms of PD and other neurodegenerative diseases.

Suzanne Angeli grew up in New Orleans, Louisiana. She received her Ph.D. in biomedical sciences from the University of California, San Francisco, where she studied how proteins misfold in neurodegenerative diseases. Currently a postdoctoral researcher at the Buck Institute for Research on Aging, Angeli uses the microscopic nematode, C. elegans, to understand how metals can impact the PD disease state as well as how mitochondria respond to stress and aging.

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